It starts at about 30 minutes into this rather excellent podcast. Here's a little excerpt where Ross starts talking about Steve Ditko's interpretation of a Spider-Man that thrives as a teenage boy, and diverging into his own opinion about a certain controversial topic:
Jonathan Ross: "If you look at what Marvel's doing with Spider-Man now of course, in the long run, he was proved right, because as soon as he became an adult - kids, and that's primarily who those books were aimed at, couldn't associate with him in any way. Y'know, I don't think any teenagers wanted to pick up Spider-Man and read about the problems he was having with his wife Mary Jane! Why do you want to read about a married superhero? Why did they let him get married, it was about the dumbest thing they ever did! Y'know, obviously I'm saying that with the benefit of hindsight, but it was stupid. I remember seeing the cover, Spider-Man gets married, I thought - oh please, for god's sake what's wrong with you."
He also says Ditko told him Spider-Man was meant to be purple and orange, instead of red and blue! I wonder if the character would still have taken off the way it did.